The calciferol receptor (VDR) is a nuclear transcription factor that is triggered by the presence of calcitriol. This forms a heterodimer with retinoid X after which enters the nucleus where it binds to specific DNA sequences called Vitamin D responsive elements.
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In mammals, the VDR plays a pivotal position in the head of hair cycle, and loss of the receptor is definitely associated with thinning hair. It is important for the induction of postnatal your hair cycle pathways and for the regulation of postmorphogenic hair cycle path ways. The VDR is expressed in the gut, the thyroid, the kidney, and numerous types of the immune system cells.
A large number of myeloid leukemia cell lines express the VDR, nevertheless at different levels. In a study of HL-60 cellular material, a chemical substance called 1, 25(OH)2D3 (10-7 M) reduced the VDR necessary protein level by simply 50% inside 24 hours. Following 72 hours, VDR health proteins amounts returned to normal. However , the drug did not affect the amount of VDR mRNA or protein expression.
Even though VDR can be expressed in the majority of neurons, it might be found in glial cells and a subset of individual primary glioblastoma cells. The protein has been immunoreactive in oligodendrocytes of the white colored matter. review Furthermore, VDR has been discovered in glial fibrillary acidic protein.